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Xiaflex Hand Contracture

What is XIAFLEX?

XIAFLEX is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18.

Important Safety Information

Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, or increased pain in your treated finger or hand after your injection or after your follow-up visit
  • Allergic reactions. Severe allergic reactions can happen in people who receive XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
    • Hives
    • Swollen face
    • Breathing trouble
    • Chest pain
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.

Please see the accompanying full Prescribing Information and Medication Guide.


Helpful downloads

Looking for more information about XIAFLEX, what to expect from treatment, and financial assistance? All printable materials can be found in the form of PDFs at the links below.

Doctor Discussion Guide

Is XIAFLEX right for you? Only your doctor can tell you for sure. These questions can help prepare you for your next appointment, so you and your doctor can make an informed decision on treatment for your Dupuytren’s contracture.

XIAFLEX Patient Brochure

The more you know about Dupuytren’s contracture, the better prepared you will be to have an informed discussion with your doctor about treatment. This brochure explains Dupuytren’s contracture, and offers additional information about XIAFLEX.

XIAFLEX Copay Card

Did you know eligible patients can save up to $1,000 on their XIAFLEX treatment? With the XIAFLEX Copay Program most people have little or no out-of-pocket expense for XIAFLEX. Use this copay card to enroll in the XIAFLEX Copay Program.

Finger Exercises

Your doctor may instruct you to do finger exercises at home following your XIAFLEX treatment. This helpful PDF serves as a guide for the exercises, and offers instructions on how to do each exercise.

Click here for more information

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